Determination of Physicochemical Properties and Monitoring Stability of Squalene Emulsions

Authors

  • E. Slepecká Department of Epizootology and Preventive Veterinary Medicine, University of Veterinary Medicine and Pharmacy, Košice, Slovakia
  • J. Süli Department of Medicinal Chemistry, University of Veterinary Medicine and Pharmacy, Košice, Slovakia
  • J. Radová Department of Medicinal Chemistry, University of Veterinary Medicine and Pharmacy, Košice, Slovakia
  • A. Ondrejková Department of Epizootology and Preventive Veterinary Medicine, University of Veterinary Medicine and Pharmacy, Košice, Slovakia
  • R. Ondrejka Department of Epizootology and Preventive Veterinary Medicine, University of Veterinary Medicine and Pharmacy, Košice, Slovakia
  • M. Prokeš Department of Epizootology and Preventive Veterinary Medicine, University of Veterinary Medicine and Pharmacy, Košice, Slovakia
  • Ľ. Korytár Department of Epizootology and Preventive Veterinary Medicine, University of Veterinary Medicine and Pharmacy, Košice, Slovakia
  • P. Čechvala Department of Epizootology and Preventive Veterinary Medicine, University of Veterinary Medicine and Pharmacy, Košice, Slovakia
  • J. Harvanová Department of Pharmaceutical Chemistry, University of Veterinary Medicine and Pharmacy, Košice, Slovakia

Keywords:

emulsion, squalene, emulsion stability

Abstract

The study deals with the preparation of stable emulsions of squalene, which are suitable for production of adjuvant inactivated vaccine. We followed the stability of emulsions prepared at a concentration of squalene 2.5 % (w/v) as well as some of their physical properties. The ideal storage conditions of squalene emulsions were determined by observing the impact of packaging materials on the stability. Higher stability of the emulsions stored in polyethylene compared with those stored in glass contai­ners was observed.

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Published

2013-08-15

How to Cite

Slepecká, E., Süli, J., Radová, J., Ondrejková, A., Ondrejka, R., Prokeš, M., Korytár, Ľ., Čechvala, P., & Harvanová, J. (2013). Determination of Physicochemical Properties and Monitoring Stability of Squalene Emulsions. Chemické Listy, 107(8), 659–664. Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/634

Issue

Vol. 107 No. 8 (2013)

Section

Articles