Interaction of Genotoxic 2-Nitrofluorene and Its Metabolites with DNA In Vivo and Its Monitoring Using Electrochemical DNA Biosensors In Vitro

Authors

  • Š. Skalová Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague, Czech Republic | J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
  • K. Stávková Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague, Czech Republic
  • A. Hájková Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague, Czech Republic
  • J. Barek Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague, Czech Republic
  • J. Fischer Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague, Czech Republic
  • J. Wang Department of Nanoengineering, University of California, San Diego, La Jolla, CA, USA
  • V. Vyskočil Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague, Czech Republic

Keywords:

nitrated polycyclic aromatic hydrocarbons, 2-nitrofluorene, DNA adducts, DNA damage detection, DNA biosensors, carbon electrodes, mercury electrodes

Abstract

This review is focused on genotoxic 2-nitrofluorene, which is a marker for the presence of nitrated polycyclic aromatic hydrocarbons, and summarizes the current knowledge about the negative effects of 2-nitrofluorene and its metabolites on living organisms, especially on their DNA. These findings obtained via in vivo investigations are compared with information obtained using electrochemical DNA biosensors, which represent very promising in vitro alternative to the study of processes proceeding in living organisms during the interaction of their DNA with various xenobiotic compounds.

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Published

2017-03-15

How to Cite

Skalová, Š., Stávková, K., Hájková, A., Barek, J., Fischer, J., Wang, J., & Vyskočil, V. (2017). Interaction of Genotoxic 2-Nitrofluorene and Its Metabolites with DNA In Vivo and Its Monitoring Using Electrochemical DNA Biosensors In Vitro. Chemické Listy, 111(3), 178–185. Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/96

Issue

Vol. 111 No. 3 (2017)

Section

Articles

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