Prostate Specific Antigen, Metallothionein and Caveolin-1 as Markers of Formation and Development of Prostate Carcinom

Authors

  • M. Sztalmachová Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno ǀ Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno
  • J. Gumulec Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno
  • N. Cernei Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno ǀ Central European Institute of Technology, Brno University of Technology, Brno
  • M. Hlavna Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno
  • O. Zítka Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno ǀ Central European Institute of Technology, Brno University of Technology, Brno
  • P. Babula Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • V. Adam Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno ǀ Central European Institute of Technology, Brno University of Technology, Brno
  • R. Kizek Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno ǀ Central European Institute of Technology, Brno University of Technology, Brno
  • M. Masařík Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno ǀ Central European Institute of Technology, Brno University of Technology, Brno

Keywords:

prostate cancer, metallothionein, prostate specific antigen, caveolin-1

Abstract

The current diagnostic limitations of prostate cancer have shown that the development of new approaches to early detection of aggressive forms of of the cancer is very important. A comprehensive approach to detection of potential tumour markers using different methods and their optimization is described. We focused on caveolin-1 and metallothionein and the obtained results were compared with prostate specific antigen as a golden standard of prostate cancer markers. All the mentioned markers were detected on both the mRNA and protein levels in three types of prostate cell lines. Metallothionein and caveolin-1 rank among the promising markers in prostate cancer diagnosis, especially for distinguishing aggressive silent forms of the disease.

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Published

2012-11-15

How to Cite

Sztalmachová, M., Gumulec, J., Cernei, N., Hlavna, M., Zítka, O., Babula, P., Adam, V., Kizek, R., & Masařík, M. (2012). Prostate Specific Antigen, Metallothionein and Caveolin-1 as Markers of Formation and Development of Prostate Carcinom. Chemické Listy, 106(11), 1075–1080. Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/819

Issue

Vol. 106 No. 11 (2012)

Section

Articles

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