Mechanism of Base Excision with the hOGG1 DNA Repair Enzyme

Authors

  • J. Šebera Department of Molecular Spectroscopy, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
  • L. Trantírek Central European Institute of Technology, Masaryk University, Brno, Czech Republic
  • J. Fukal Department of Molecular Spectroscopy, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
  • Y. Tanaka Division of Pharmaceutical Chemistry, Tohoku University, Aobayama, Aoba-ku, Sendai, Japan
  • V. Sychrovský Department of Molecular Spectroscopy, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Keywords:

hOGG1, base excision repair, theoretical modelling, N-pyramidalization

Abstract

This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substrate-specific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.

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Published

2014-04-15

How to Cite

Šebera, J., Trantírek, L., Fukal, J., Tanaka, Y., & Sychrovský, V. (2014). Mechanism of Base Excision with the hOGG1 DNA Repair Enzyme. Chemické Listy, 108(4), 364–367. Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/525

Issue

Vol. 108 No. 4 (2014)

Section

Articles