Utilizing Self-Emulsifying Drug Delivery Systems in Drug Solubility and Bioavailability Improvement

Authors

  • L. Seilerová Department of Solid State Chemistry, Institute of Chemical Technology, Prague
  • V. Sieberová Department of Solid State Chemistry, Institute of Chemical Technology, Prague
  • B. Kratochvíl Department of Solid State Chemistry, Institute of Chemical Technology, Prague
  • D. Vetchý Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno

Keywords:

SEDDS, self-emulsifying systems, solubility improvement

Abstract

Liphophilic formulations of pharmaceuticals are very promising methods of drug solubility improvement. Four types of the formulations are available: Self-emulsifying drug delivery systems (SEDDS) consist of oils, surfactants and cosolvents where the pharmaceutical ingredients are dissolved. These systems form o/w emulsions which can be administered in tablets, soft or hard gelatin capsules. The effectivity of SEDDS depends on many parameters, such as excipients or emulsion droplet size.

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Published

2014-10-15

How to Cite

Seilerová, L., Sieberová, V., Kratochvíl, B., & Vetchý, D. (2014). Utilizing Self-Emulsifying Drug Delivery Systems in Drug Solubility and Bioavailability Improvement. Chemické Listy, 108(10), 956–960. Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/450

Issue

Vol. 108 No. 10 (2014)

Section

Articles