Polymorphism of Major Histocompatibility System of Man – Its Function, Indication, Detection and Interpretation

Authors

  • M. Dobrovolná Institute of Hematology and Blood Transfusion, Prague
  • M. Vraná Institute of Hematology and Blood Transfusion, Prague
  • J. E. Dyr Institute of Hematology and Blood Transfusion, Prague

Keywords:

major histocompatibility complex, human leukocyte antigen, immunity

Abstract

The major histocompatibility system of man is the genetic system of the human leukocyte antigen, the most polymorphic region of the human genome, which determines the function and individual parameters of the immune system. Faulty immune response to antigenic stimulus may manifest itself as hypersensitivity, immunodeficiency or autoimmunity. Detection of this polymorphism and study of its functional behavior can be of help in elucidation of the pathogenesis of many diseases and thus to contribute to their immunotherapeutic treatment.

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Published

2015-01-15

How to Cite

Dobrovolná, M., Vraná, M., & Dyr, J. E. (2015). Polymorphism of Major Histocompatibility System of Man – Its Function, Indication, Detection and Interpretation. Chemické Listy, 109(1), 45–50. Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/413

Issue

Vol. 109 No. 1 (2015)

Section

Articles