Voltammetric Determination of Metronidazole Using a Silver Solid Working Electrode

Abstract

Metronidazole (MND) is an antibiotic drug used to treat severe bacterial infections (e.g., of the central nervous system, lungs and respiratory tract, digestive tract, or female genital organs). In this work, a new voltammetric method for the determination of MND on a silver solid electrode was developed. Under optimum conditions (Britton-Robinson buffer of pH 10.0 used as a supporting electrolyte and electrochemical regeneration of the working electrode surface applied to eliminate its passivation), a linear calibration dependence of MND was recorded in the concentration range from 1 to 400 μmol L⁻¹, with the limits of detection (LOD) and quantification (LOQ) of 0.55 μmol L⁻¹ and 1.8 μmol L⁻¹, respectively.

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