The Influence of Persistent Organic Pollutants on Mitochondrial Functions and Origin of Metabolic Syndrome

Authors

  • J. Dvořáková Department of Public Health and Preventive Medicine, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen
  • M. Kripnerová Institute of Biology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen
  • M. Čedíková Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen | Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen
  • V. Babuška Institute of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen
  • V. Kulda Institute of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen
  • M. Pešta Institute of Biology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen | Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen
  • M. Králíčková Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen | Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen
  • D. Müllerová Department of Public Health and Preventive Medicine, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen

Keywords:

persistent organic pollutants, mitochondria, diabetes mellitus, obesity, metabolic syndrome

Abstract

Persistent organic pollutants are bioaccumulative and toxic to living organisms. Persistent substances may increase oxidative stress and start inflammatory processes, which are the major factors in the pathogenesis of obesity-related diseases. A clear link was found between mitochondrial dysfunction and the type 2 diabetes mellitus. A mutation in mitochondrial DNA β-cells of pancreas leads to the worsening of insulin secretion, cell apoptosis and subsequent reduction of β-cells.

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Published

2015-06-15

How to Cite

Dvořáková, J., Kripnerová, M., Čedíková, M., Babuška, V., Kulda, V., Pešta, M., Králíčková, M., & Müllerová, D. (2015). The Influence of Persistent Organic Pollutants on Mitochondrial Functions and Origin of Metabolic Syndrome. Chemické Listy, 109(6), 418–423. Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/356

Issue

Vol. 109 No. 6 (2015)

Section

Articles

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