Aluminium Participation in the formation of Reactive Oxygen Species (ROS) and Consequences of These Reactions in Chemical and Biological Systems

Authors

  • L. Hrdlička Department of Environmental Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia
  • J. Prousek Department of Environmental Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia

Keywords:

aluminium, hydroxyl radical, superoxide, oxidative stress

Abstract

A new insight into Al chemistry is presented. The published results unambiguously confirmed the production of ROS such as superoxide (O2–•) and hydroxyl radical (HO•) in the presence of Al0 under acid conditions. This finding has very important consequences for the correct understanding of underlying toxicity mechanism in biolo­gical systems. It is well known that dementia, Alzheimer and Parkinson diseases and microcytic anemia are associated with Al exposure. In addition, Al promotes biological oxidation such as lipid peroxidation, both in vitro and in vivo. A number of mechanisms have been proposed to account for the pro-oxidative effects of Al. The results suggest a contribution of two reaction mechanisms – participation of ROS and dioxirane radical intermediates.

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Published

2015-12-15

How to Cite

Hrdlička, L., & Prousek, J. (2015). Aluminium Participation in the formation of Reactive Oxygen Species (ROS) and Consequences of These Reactions in Chemical and Biological Systems. Chemické Listy, 109(12), 923–929. Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/274

Issue

Vol. 109 No. 12 (2015)

Section

Articles