Determination of Toxicity of Binary Mixtures Using Rat Hepatocytes

Authors

  • A. Pokorná National Institute of Public Health, Prague
  • M. Tichý National Institute of Public Health, Prague
  • J. Nerudová National Institute of Public Health, Prague
  • J. Tumová National Institute of Public Health, Prague
  • I. Hanzlíková National Institute of Public Health, Prague

Abstract

Primary hepatocyte assay was used to determine acute toxicity of nickel(II) chloride - 3,4-dichloroaniline and nickel(II) chloride - sodium diclophenac mixtures. Although the components act by different mechanisms, their acute toxicity was almost additive; it decreased to zero in dependence on the molar ratio of the components. Toxicities of pollutants in environment may decrease due to interactions with other components.

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Published

2009-08-15

How to Cite

Pokorná, A., Tichý, M., Nerudová, J., Tumová, J., & Hanzlíková, I. (2009). Determination of Toxicity of Binary Mixtures Using Rat Hepatocytes. Chemické Listy, 103(7). Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1517

Issue

Vol. 103 No. 7 (2009)

Section

Articles