Voltampérometrické stanovenie epinefrínu v ľudskom moči využitím bórom dopovanej diamantovej filmovej elektródy

Abstrakt

An unmodified boron-doped diamond (BDD) electrode was used in combination with square-wave voltammetry (SWV) in a simple, rapid and inexpensive method for the detection and determinativ of adrenaline. A low detection limit of 2·10^–7 mol l^–1 attained on BDD electrode was due to a very high signal-to-noise (S/N) ratio. The proposed procedure was applied to analysis of human urine spiked with adrenaline giving good recovery values. Matrix effects did not present any significant interference. BDD electrode may be used as a sensitive drug sensor in clinical analysis of various biologically active compounds and may replace complex and expensive chromatographic and spectral methods. Howe­ver, the usefulness of this method can be limited in clinical analysis in the presence of other drugs in urine, e.g. ascorbic acid and uric acid.