Onkogénne formy izocitrátdehydrogenázy: Mechanizmy karcinogenézy a vzniku rezistencie na chemoterapeutiká

Abstrakt

Many types of tumors harbor a mutation in the gene for the metabolic enzyme isocitrate dehydrogenase resulting in the production of the oncometabolite ᴅ-2-hydroxy glutarate with a pleiotropic effect on the cell. The paper provides an overview of the latest knowledge of the me­chanism of carcinogenesis, of specific drugs suppressing ᴅ-2-hydroxy glutarate production and of the causes of resistance complicating treatment based on specific inhibitors of oncogenic forms of isocitate dehydrogenase.