Prolyloligopeptidasa ve fyziologii a patologii

Abstrakt

Prolyl oligopeptidase is an atypical serine peptidase which digests bioactive peptides, including hormones and neuropeptides. Prolyl oligopeptidase cleaves internal peptide bonds on the C-terminal side of proline residues. Orthologous enzymes are found in plants, bacteria, fungi, protozoa, invertebrates and vertebrates. This review provides an update on function and structure of prolyl oligopeptidase; it is also focused on its biological role and implication in physiological processes and disorders.