Activation of G-Proteins by Metabotropic Glutamate Receptors and GABA B Receptors

  • J. Blahos Department of Molecular Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague
  • M. Havlickova Department of Molecular Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague
  • A. Zikova Department of Molecular Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague
  • J. Trojanova Department of Molecular Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague
  • B. Hruskova Department of Molecular Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague
  • D. Frankova Department of Molecular Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague
  • V. Hlavackova Department of Molecular Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague

Abstrakt

This review summarizes new findings on family 3 G-protein coupled receptors, also called metabotropic glutamate receptor (MGR) family, with respect to G-protein activation. In our studies we try to map the interface, which is crucial for G-protein activation. The interface includes intracellular loops of MGR, the loops 2 and 3 being especially important. On the GABAB receptor, the GB2 subunit contains enough molecular determinants for G-protein activation. Similarly to MGR, also here the corresponding intracellular loops are involved. On the G-protein side, the N-terminal preB1 region, C-terminal L9 loop and the extreme C-terminus are likely to contact the receptors in their active state.
Publikované
2004-02-15
Jak citovat
[1]
Blahos, J., Havlickova, M., Zikova, A., Trojanova, J., Hruskova, B., Frankova, D. a Hlavackova, V. 2004. Activation of G-Proteins by Metabotropic Glutamate Receptors and GABA B Receptors. Chemické listy. 98, 1 (úno. 2004).
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Články