Chelates for Biomedicinal Use

Autoři

  • J. Kotek Department of Inorganic Chemistry, Faculty of Science, Charles University, Prague
  • I. Lukeš Department of Inorganic Chemistry, Faculty of Science, Charles University, Prague

Abstrakt

Magnetic resonance imaging (MRI) and positron emission tomography (PET) have gained a great importance in the last thirty years in medicinal diagnostics as imaging techniques with a superior spatial resolution and contrast. MRI has assumed a critical role in medicinal diagnosis and applications of contrast agents (CAs), mostly based on Gd(III) complexes. For this purpose, specific CAs have been developed, changing relaxivity after cleavage of some bonds sensitive to the presence of specific ions or metabolites. For PET applications, a new isotope 68Ga(III) has been proposed. In view of utilization of toxic ions, the crucial condition for their applications in vivo is their complexation in stable species. In this review, the ligand types and structures of their complexes as well as their physicochemical parameters are discussed.

Publikováno

15.01.2011

Jak citovat

Kotek, J., & Lukeš, I. (2011). Chelates for Biomedicinal Use. Chemické Listy, 104(12). Získáno z http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1208

Číslo

Sekce

Články

Nejaktuálnější články stejného autora (stejných autorů)