Current Topics in the Asymmetric Transfer Hydrogenation of Imines

Authors

  • J. Januščák Department of Organic Technology, University of Chemistry and Technology, Prague
  • J. Václavík Department of Organic Technology, University of Chemistry and Technology, Prague | Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
  • P. Šot Department of Organic Technology, University of Chemistry and Technology, Prague
  • J. Pecháček Department of Organic Technology, University of Chemistry and Technology, Prague
  • B. Vilhanová Department of Organic Technology, University of Chemistry and Technology, Prague
  • M. Kuzma Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
  • P. Kačer Department of Organic Technology, University of Chemistry and Technology, Prague

Keywords:

asymmetric transfer hydrogenation, ruthenium, isoquinoline, enantioselective catalysis

Abstract

At present, asymmetric hydrogenation is an attractive method for the synthesis of enantioenriched chiral compounds, such as drugs, agrochemicals or fragrances. This review is focused on the asymmetric transfer hydrogenation (ATH) of imines, in particular 3,4-dihydro­isoquinolines. Mechanistic aspects of ATH are discussed and analytical methods for the monitoring of ATH as developed in our group are presented. The effect of structural changes of the catalyst and substrate on the course of ATH is also described. The influence of tempe­rature, reactant concentrations and other reaction parameters as well as the utilizability of ATH in chemical industry are discussed.

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Published

2015-07-15

How to Cite

Januščák, J., Václavík, J., Šot, P., Pecháček, J., Vilhanová, B., Kuzma, M., & Kačer, P. (2015). Current Topics in the Asymmetric Transfer Hydrogenation of Imines. Chemické Listy, 109(7), 492–498. Retrieved from http://w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/341

Issue

Vol. 109 No. 7 (2015)

Section

Articles

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